Many studied have reported increased in antioxidant capacity of plasma following consumption of antioxidant rich fruits, vegetables, tea, wines and grape juices. Pomegranate tree (Punica Granatum L) originated in the Middle East and India (Punica Granatum L) and has been used for centuries in ancient cultures for its medicinal purpose. It is widely acknowledged for antioxidant properties, which are higher than most other fruit- related food items that were originally thought to contain the highest amounts of antioxidants. In the present study, the ferric reducing\antioxidant power assay (FRAP assay) was employed and the effect of pomegranate fresh fruit consumption on the plasma antioxidant capacity of healthy volunteers was assessed. Thirty healthy volunteers were recruited for study and were randomly divided into three groups. For the first group (group A) the pomegranate fresh fruit (100 gr/day for ten days) was added to their diet. The subjects in the second group (group B) consumed vitamin E (400units/days). For the third group (group C), the subjects have not to intake vitamin E and pomegranate and other antioxidant compounds for ten days. This group consumed tap water. Blood samples were collected, after at least 12 hour overnight fast, the day before beginning supplementation period and the day after supplementation had finished. The paired sample t-test revealed that antioxidant value determined after vitamin E and pomegranate intake were statistically higher than those determined before ingestion (8.5 and 14%, p<0.005), but this different was not significant in group C who consumed water.